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Over 1600 potential interactions between natural products and conventional drugs identified by research group; 25% rated as severe
May 18, 2007 — Stockton, CA —
A 55-year-old man thought he was doing the right thing for his health when he stopped by the health food store and was advised to take several supplements.
He didn't realize that one of the natural medicines he began to take, ginkgo, could reduce the effectiveness of the medication
he took to control his seizures. He suffered a seizure while swimming, and died.
People often think "natural equals safe." They don't realize that some natural products can contribute to dangerous interactions.
Since 1998, researchers and editors from
Natural Medicines Comprehensive Database,
the leading medical reference on natural products, have been compiling and analyzing data on how natural products interact with
drugs. To date, they have identified over 1600 potential interactions.
"The potential for these interactions is huge," says Phil Gregory, PharmD, Editor of Natural Medicines Comprehensive Database.
"Many people who take natural products are already taking several prescription drugs. With each new drug and natural product
that is added, the risk of an interaction increases exponentially."
The research team at Natural Medicines Comprehensive Database has just completed a major new initiative to provide
evidence-based ratings for every potential natural product-drug interaction. Now all of these interactions have been
critically evaluated and rated as Major, Moderate, or Mild. An intuitive stop-light system shows which combinations
absolutely should not be used together, and which ones are of less concern.
"This is a tremendous time saver for busy health professionals," says Dr. Gregory. "Pharmacists, physicians, and other clinicians
can now simply input a list of medications and natural products that their patient takes, click a button, and instantly see
which interactions they need to be most concerned about."
About 25% of these interactions are rated as Major. About 65% are Moderate and 10% are Mild.
Some important examples include the following:
St. John's wort interacts with oral contraceptives. This combination can result in ineffective birth control and an
unplanned pregnancy. Women taking oral contraceptives should use a back-up form of birth control if they take St. John's wort.
Garlic interacts with HIV medications. Taking garlic might cause treatment failure with serious consequences in an
HIV/AIDS patient. Patients taking HIV medications should avoid garlic supplements.
Bitter orange interacts with heart medications, which can cause life-threatening arrhythmia. Bitter
orange has also been linked to severe side effects,including heart attack and stroke. It's one of the most common
ingredients in weight loss supplements, but is not safe for most people.
Ginkgo can cause dangerous seizures in people with epilepsy. People with a history of seizure should not take ginkgo.
Black cohosh could make some chemotherapy drugs less effective, and potentially reduce the benefit of a cancer treatment.
Red clover interacts with tamoxifen. Breast cancer patients on tamoxifen often have hot flashes and often take
supplements to try to stop hot flashes. These patients should avoid the many supplements that contain red clover, as this
mixture might decrease the anticancer effects of tamoxifen.
Dong quai interacts with warfarin and could result in life-threatening bleeding.
A new special report is now available at
www.naturaldatabase.com
to educate health professionals on how to determine which drug-supplement interactions are significant and how to use the
Interaction Ratings.
Thousands of clinicians throughout the U.S., Canada, Australia, United Kingdom, Japan, and other countries rely on the
Natural Medicines Comprehensive Database for scientifically reliable data on natural medicines. This resource is
often provided by government agencies, hospitals, or other institutions for the use of physicians, pharmacists, dietitians,
researchers and others. The new Interaction Ratings are now incorporated into Natural Medicines Comprehensive Database
for all subscribers.
Consumers can access this unbiased information on safety, effectiveness, and drug interactions with dietary supplements. It
appears in a consumer-friendly format as
Natural Medicines Comprehensive Database CONSUMER Version, at
www.naturaldatabaseconsumer.com.
In addition, the editors also provide this resource to Consumer Reports, so that consumers can access it at
ConsumerReportsMedicalGuide.org.
Researchers and editors add new information to Natural Medicines Comprehensive Database daily. It is listed as a
Recommended Evidence-Based Reference. It is available in book form, on the Internet, and is
downloadable to PDA.
Thousands of pharmacists, physicians, regulatory health agencies, pharmacies, educators and students worldwide rely on
Natural Medicines Comprehensive Database regularly.
About Therapeutic Research
Therapeutic Research is a completely independent research and publishing organization that provides evidence-based
information for physicians, pharmacists, and other medical professionals. Therapeutic Research publishes
Natural Medicines Comprehensive Database,
Pharmacist's Letter,
Prescriber's Letter,
Ident-A-Drug Reference,
and a variety of continuing medical education courses including live courses. Therapeutic Research accepts no advertising and
provides objective information for subscribers.
Contact
Julie McCloud
Therapeutic Research Center
Therapeutic Research Faculty
3120 West March Lane
Stockton, CA 95219
Phone: 209-472-2244
Fax: 209-472-2247
http://www.therapeuticresearch.com/newsroom
julie.mccloud@pletter.com
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